DSIP Peptide
Start provider review

Compounded, not FDA-approved

The peptide named for delta sleep is the thing its own trials kept failing to find

DSIP stands for delta sleep-inducing peptide, a name assigned in 1977 for what the molecule did to rabbit EEGs. In people, the record reads differently: the only parallel-group placebo-controlled insomnia trial ever run, 16 patients in 1992, concluded it is not likely to be of major therapeutic benefit, and the most recent human study, in 2009, found it paradoxically reduced the delta rhythm it is named for. The peptide's own gene, precursor and receptor have never been found. In July 2026 FDA proposed keeping it out of compounding pharmacies, and trade press reports the advisory committee agreed, making it the only one of seven peptides reviewed that was voted down. Every study in our table is labeled by species, every claim carries its grade, and the absences are printed at the same weight as the findings.

Start provider reviewBrowse the guides
  • 419papers indexed on this peptide, with a median publication year of 1992 and only 7 since 2016
  • 5randomized-tagged studies in that entire literature, enrolling 72 people between them
  • 16patients in the largest placebo-controlled insomnia trial, which concluded DSIP is not likely to be of major therapeutic benefit
  • 28rows in our evidence table, each labeled by species, including 5 documented absences of evidence
  • 42fetch-verified citations, 97.6 percent peer-reviewed or government sources; the single press citation is the attributed committee-vote report

Online care, from intake to delivery

DSIP care, made simple

Choose your plan, complete a private medical intake, and connect with a licensed provider. If prescribed, treatment ships discreetly to your door.

DSIP care catalog product image
Compounded injectable treatmentPrepared after approval
Catalog image. Dispensed product and packaging may vary by pharmacy.

Your care plan includes

Everything you need to get started

From$143.10per month
Licensed providerMedical reviewIf prescribedTreatment includedAt no added costDiscreet shippingWhen you need itOrder support
Choose your planChange or cancel future refills anytime
Due today$161.10then monthly

Encrypted checkout • provider review required • shipping included

  1. 01
    Choose your planSelect the supply and refill preference that works for you.
  2. 02
    Complete your intakeShare your health history in our private, secure flow.
  3. 03
    Provider reviewIf appropriate, your prescription is prepared and shipped.

Prescription treatment requires an online medical evaluation. A provider will determine whether treatment is medically appropriate; approval is not guaranteed.

Key facts

  • StatusCompounded, not FDA-approved
  • Human half-lifeNot establishedsource
  • Human bioavailability (any route)Not establishedsource
  • Human Cmax or AUCNot establishedsource
  • Published human PK studies0source
  • Half-life, dog, IV4.0 +/- 0.7 minutessource
  • Metabolic clearance rate, dog, IV30.7 +/- 2.5 mL/kg per minutesource
  • Stability in blood (in vitro)Rapid degradation; analogs aggregatesource
  • Water solubility (free base)About 0.5 mg/mL; sold 1 mg/mL labels questioned by FDAsource
  • ClassSynthetic nonapeptide; sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-GluChemical referencesource
  • Molecular weight848.8 Da (C35H48N10O15)Chemical referencesource
  • CAS / UNII62568-57-4 / YN28Z5YZ73Chemical referencesource
  • INNEmideltide (used by exactly one indexed paper, ever)Analytical studysource
  • MeSH descriptorD003701Chemical referencesource
  • Discovered1977, isolated from cerebral venous blood of sleep-stimulated rabbitsAnimalsource
  • US FDA statusNot approved for any use; on FDA's compounding safety-risks listRegulatory recordsource
  • July 2026 PCACFDA proposed emideltide NOT be added to the 503A Bulks ListRegulatory recordsource
  • Committee vote (press-reported)Rejected 6-7 with one abstention, per Regulatory Focus; the only one of seven peptides voted downRegulatory recordsource
  • Uses FDA evaluatedOpioid withdrawal, chronic insomnia, narcolepsyRegulatory recordsource
  • Route in every clinical studyIntravenous infusion, 25 to 150 nmol/kgRegulatory recordsource
  • Total documented IV exposure209 subjects, 1 to 15 days (FDA count)Regulatory recordsource
  • Data for the sold SC/nasal routesNone identified by FDAAbsence of evidencesource
  • Indexed literature419 records; median year 1992; 7 since 2016Analytical studysource
  • RCT-tagged records5, enrolling 72 people in totalAnalytical studysource
  • Registered clinical trials today0Absence of evidencesource
  • Gene, precursor protein, receptorNever identifiedReview or guidelinesource

Read the full DSIP (emideltide) monograph

Browse by topic

Everything on DSIP (delta sleep-inducing peptide), organized the way you research it.

Evidence22 articlesSourcing8 articlesSafety7 articlesDosing7 articlesComparisons4 articles

Free DSIP (emideltide) tools

Practical calculators and references, each scoped and sourced.

Review-gated tools: these tools are excluded from search and AI citation and must not be used as dosing, reconstitution, injection, or treatment instruction.

T-01Reconstitution calculator (no-label model)Converts a vial's stated peptide content and added diluent volume into concentration, dose volume and U-100 syringe units. All inputs are user-entered; there are no label constants because no label exists.T-03Study-dose explorerEvery regimen in the DSIP clinical literature, attached to the study that used it, its design, its size, and what it actually found, including the null results. Filterable by indication, design and result direction.

All guides

48 in-depth, individually cited guides.

Review-gated archive: the guides below are preserved for individual medical and source review. They are excluded from search indexing and AI citation files.

Evidence 22 guides

DSIP alternatives: what the research actually supportsDSIP's human sleep data is thin and decades old. Here's how melatonin, magnesium, CBT-I, and other peptides compare on actual evidence.Updated 2026-07-30Read guide →
DSIP for beginners: what the research actually showsA plain guide to DSIP for beginners: what the 1970s-90s studies found, what's still preclinical, dosing patterns in the literature, and honest limits.Updated 2026-07-30Read guide →
DSIP frequently asked questions: what the research saysStraight answers on DSIP peptide: how it's studied, dosing in trials, sleep evidence quality, safety data, and legal status. Sourced to the actual studies.Updated 2026-07-30Read guide →
DSIP in older adults: what the research actually showsDSIP's human sleep data comes mostly from small trials in the 1980s-90s, some in elderly insomniacs. Here's what those studies found, and didn't.Updated 2026-07-30Read guide →
DSIP myths vs facts: what the research actually showsDSIP's human sleep data is mostly small 1980s-90s trials, not modern proof. We separate what's documented from what's marketing spin, study by study.Updated 2026-07-30Read guide →
DSIP pros and cons: what the research actually supportsDSIP's evidence is mostly 1980s-90s animal and small human studies. Here's an honest breakdown of the real pros and cons before you consider it.Updated 2026-07-30Read guide →
DSIP success rate: what the actual research showsThere is no verified DSIP success rate for human sleep. Here's what the 1980s-90s trials, doses, and sample sizes actually found, and what's missing.Updated 2026-07-30Read guide →
How long until DSIP works? What the timeline actually isHonest timeline for DSIP peptide effects: what old human studies measured, how fast, and why the real answer is nobody has solid modern data confirming it.Updated 2026-07-30Read guide →
Natural alternatives to DSIP: what actually has evidenceDSIP's human sleep data is thin and decades old. Here's what magnesium, glycine, L-theanine, and melatonin actually show in real clinical trials.Updated 2026-07-30Read guide →
Does dsip peptide work? what the actual studies showdoes dsip peptide work for sleep? the human data is thin, mostly from the 1980s-90s, and mixed. here's every study, honestly assessed.Updated 2026-07-26Read guide →
DSIP peptide: what the sleep research actually showsDSIP (delta sleep-inducing peptide) research is mostly 1970s-90s animal and small human data. Here's what's real, what's thin, and what's marketing.Updated 2026-07-26Read guide →
DSIP animal studies vs human evidence: what's realDSIP's sleep claims trace to 1970s-90s rat and cat studies. Human trials are small, old, and mixed. Here's what the actual record shows.Updated 2026-07-26Read guide →
DSIP before and after claims: what the evidence really showsDSIP before and after claims mostly come from forums, not trials. Here's what the actual 1980s-90s research found, and what's missing for humans.Updated 2026-07-26Read guide →
DSIP clinical trials: what the human studies actually showDSIP's human sleep trials date to 1977-1993 and are small and mixed. Here's what each study found, what it didn't, and why the evidence is thin.Updated 2026-07-26Read guide →
DSIP human studies: what the actual research showsDSIP human data is small, old, and mixed. Here's what the 1980s-90s trials on sleep, cortisol, and withdrawal actually found, and what's still missing.Updated 2026-07-26Read guide →
DSIP results: what the research actually showsDSIP's sleep evidence comes mostly from 1970s-90s animal and small human studies. Here's what those trials found, what they didn't, and what's still unknown.Updated 2026-07-26Read guide →
DSIP stacks with other peptides: what the evidence supportsNo published trial tests DSIP combined with other peptides. Here's what the individual research on DSIP, other sleep peptides, and stacking logic actually shows.Updated 2026-07-26Read guide →
How does DSIP peptide work? the mechanism, explainedDSIP was proposed to cross the blood-brain barrier and act on GABA and opioid pathways. Most evidence is 1980s rat data, not proven human sleep effects.Updated 2026-07-26Read guide →
How long does DSIP take to work for sleep?Honest answer: there's no confirmed human onset time for DSIP. Old preclinical studies suggest minutes to hours in animals. Here's what the record actually shows.Updated 2026-07-26Read guide →
How to take DSIP peptide: dosing, timing, and routeDSIP is dosed around 100-300 mcg subcutaneous before bed in the old human trials. Here's what the studies actually did, and what remains unproven.Updated 2026-07-26Read guide →
Is DSIP FDA approved? The honest regulatory answerNo. DSIP has zero FDA-approved indications and no NDA on file. Here's what the actual regulatory and study record shows, in plain terms.Updated 2026-07-26Read guide →
What does DSIP actually do? the real research recordDSIP's human sleep data comes from a handful of small 1970s-80s trials with mixed results. Here's what the studies actually measured, and what they didn't.Updated 2026-07-26Read guide →

Sourcing 8 guides

DSIP compounded vs brand name: what you're actually buyingThere is no FDA-approved DSIP brand. Every legal source is a compounded or research-use product. Here's what that means for quality, price, and risk.Updated 2026-07-30Read guide →
DSIP telehealth options: what's real, what's notDSIP telehealth options explained: FDA's 2024 bulk ban, why most clinics can't legally prescribe it, and what provider-reviewed sourcing actually looks like.Updated 2026-07-30Read guide →
Where to buy dsip legally: a buyer's reality checkDSIP isn't FDA-approved for any use. Here's what "legal" actually means for research peptides, how sourcing works, and how to check a supplier before you pay.Updated 2026-07-30Read guide →
Buy DSIP: what you're actually getting and why it mattersThinking about buying DSIP peptide? Here's the real evidence base, sourcing risks, price ranges, and why unregulated vials are riskier than they look.Updated 2026-07-26Read guide →
DSIP certificate of analysis explained: what to checkA DSIP COA should show identity, purity by HPLC, and mass by MS. Here's what a real one looks like and the red flags most buyers miss.Updated 2026-07-26Read guide →
DSIP prescription requirements: what's actually legal hereDSIP isn't FDA-approved for any use, so there's no real prescription pathway. Here's what the regulatory status actually means for buyers in 2025.Updated 2026-07-26Read guide →
DSIP purity and testing: what a COA actually provesDSIP is not FDA-approved for any use. Here's how to read a certificate of analysis, what purity numbers mean, and where the human data really stands.Updated 2026-07-26Read guide →
How to verify DSIP quality before you buy or use itNo FDA-approved DSIP product exists. Here's how to check COAs, third-party testing, and sourcing red flags before you trust a vial.Updated 2026-07-26Read guide →

Safety 7 guides

Dsip common mistakes people make with dosing and claimsThe most common DSIP mistakes: treating 1980s animal data as human proof, guessing at dosing, ignoring purity testing, and expecting nightly sleep effects.Updated 2026-07-30Read guide →
DSIP overdose and toxicity: what the research actually showsNo published human LD50 or overdose case reports exist for DSIP. Here's what animal toxicity studies and self-injection risks actually show, and what's unknown.Updated 2026-07-30Read guide →
DSIP withdrawal and stopping: what actually happensDoes stopping DSIP cause withdrawal or rebound insomnia? Here's what the thin human study record actually shows, and how people taper it in practice.Updated 2026-07-30Read guide →
DSIP drug interactions: what's known, what isn'tNo formal human interaction studies exist for DSIP. Here's what the 1980s-90s research suggests about sedatives, opioids, and hormone drugs, and why caution matters.Updated 2026-07-26Read guide →
DSIP long term side effects: what the research actually showsNo published human trial has tracked DSIP beyond a few weeks. Here's what the 1980s-90s studies found, and what's simply unknown about long-term use.Updated 2026-07-26Read guide →
DSIP peptide side effects: what the research actually showsDSIP side effect data comes mostly from small 1980s-90s studies. Here's what was reported, what's unknown, and how it compares to other sleep peptides.Updated 2026-07-26Read guide →
Is DSIP safe? What the human and animal data actually showDSIP's safety record comes from a handful of small, old trials and animal studies. Here's what's documented, what's missing, and what that means for you.Updated 2026-07-26Read guide →

Dosing 7 guides

DSIP cycle length: what the research actually supportsHow long should a DSIP cycle run? The honest answer, based on old human trials and animal data, plus what nobody actually knows.Updated 2026-07-26Read guide →
DSIP dosage calculator: why math alone can't set your doseNo validated DSIP dosage calculator exists. Human trials used 25-100 mcg doses; here's the actual study data and why a calculator can't replace it.Updated 2026-07-26Read guide →
How to inject DSIP: subcutaneous technique, step by stepDSIP is typically drawn up and injected subcutaneously, similar to other research peptides. Here's the actual technique, site rotation, and what the evidence supports.Updated 2026-07-26Read guide →
DSIP peptide injection: reconstitution and use, explainedHow DSIP peptide injection actually works, reconstitution steps, dosing basics, and why human sleep evidence is still thin. Study-based, not marketing.Updated 2026-07-26Read guide →
DSIP storage and shelf life: how to keep it stableLyophilized DSIP stays stable refrigerated or frozen for months to years; once reconstituted, use it within roughly 2-4 weeks refrigerated. Details and sourcing here.Updated 2026-07-26Read guide →
DSIP timeline: what to expect, day by day and week by weekWhat actually happens after a DSIP dose, and what the 1980s-90s human trials really showed about timing. No promised sleep-onset minutes exist in the record.Updated 2026-07-26Read guide →
How to reconstitute DSIP: a step-by-step protocol guideHow to reconstitute DSIP peptide with bacteriostatic water, correct dilution math, storage rules, and what the actual sleep research does (and doesn't) support.Updated 2026-07-26Read guide →

Comparisons 4 guides

DSIP vs epitalon: how the sleep evidence stacks upDSIP and epitalon both come from 1970s-90s Russian and Italian labs. Neither has modern human sleep trials. Here's what the actual studies show.Updated 2026-07-26Read guide →
DSIP vs GABA: comparing the sleep evidence honestlyDSIP has thin, decades-old human data. GABA oral supplements have weak absorption evidence. Neither beats a benzodiazepine or z-drug in real trials.Updated 2026-07-26Read guide →
DSIP vs magnesium: comparing the sleep evidence head to headDSIP has thin, mostly 1980s-90s data (some preclinical). Magnesium has real human RCTs but modest effects. Compare the actual evidence here.Updated 2026-07-26Read guide →
DSIP vs trazodone: comparing the evidence for sleepDSIP has thin, decades-old human sleep data; trazodone is FDA-approved for depression and widely used off-label for insomnia. Here's the actual comparison.Updated 2026-07-26Read guide →

Email me when the FDA rulemaking lands

The July 2026 proposal is not a final decision. One email when it becomes one. Nothing else.

Free. No spam, unsubscribe anytime. Your address is used for this brief and nothing else.

Start provider review